Effects of Soybean Metabolites on Prostate Cancer / 대한비뇨기과학회지

PURPOSE: It has been postulated that soybean isoflavones act as inhibitory factors in several cancers. Recently, various in vitro and in vivo experimental studies have demonstrated that these isoflavones inhibit prostate cancer. Therefore, we investigated whether soybean isoflavones influenced the development of prostate cancer by comparing the levels of circulating isoflavones between prostate cancer patients and controls. MATERIALS AND METHODS: The serum levels of genistein, daidzein and equol were determined using reverse-phase, high-performance liquid chromatography-multiple reaction ion monitoring mass spectrometry(HPLC-MS) and compared in 122 experimental subjects(61 prostate cancer patients and 61 cancer-free controls) from 6 hospitals. RESULTS: The serum concentrations of genistein, daidzein and equol in the patients were 130.7+/-181.4ng/ml, 53.6+/-69.3ng/ml and 11.37+/-43.4ng/ml, with control values of 95.6+/-95.2ng/ml, 55.2+/-121.8ng/ml and 23.2+/-34.5ng/ml, respectively. There was no statistical difference between the 2 groups. Daidzein non-metabolizers who were unable to degrade daidzein into equol were compared between the patients and the controls, and were found to be significantly more common in the patient group (p=0.001, OR=3.44, 95% CI=1.6243-7.2855). However, the equol/daidzein ratio was significantly lower in the patients than in the controls(p=0.0072). No association between age, stage, Gleason score or isoflavone concentrations was found. CONCLUSIONS: These results suggest that the capability to produce equol (i.e., the mechanism for the metabolism of daidzein into equol) is closely involved in the lower incidence of prostate cancer, and that a diet based on soybean isoflavones would be useful in preventing prostate cancer.

A Case of Nephrogenic Diabetes Insipidus Complicated with Bilateral Hydroureteronephrosis and Myogenic Failure of the Bladder / 대한비뇨기과학회지

No abstract available.

A Case of Sarcomatoid Renal Cell Carcinoma with Multiple Renal Stones and Pyonephrosis / 대한비뇨기과학회지

Sarcomatoid renal cell carcinoma is uncommon and constitutes approximately 1.0% to 1.5% of all renal parenchymal tumors. Renal tumors that consist of epithelial and sarcomatoid components were called Sarcomatoid renal cell carcinomas. Its distinction from other morphological variants of renal cell carcinoma is significant, because it has been shown to have a much poorer prognosis than the purely epithelial tumors. The diagnosis of sarcomatoid renal cell carcinoma is usually made when epithelial and sarcomatoid components are mixed in nephrectomy specimen. A case of sarcomatoid renal cell carcinoma is herein presented in a 77 year-old women. she complained right flank pain and high fever for 3 days, radical nephrectomy was performed and diagnosis was made by H-E stains and immunohistochemical stains of nephrectomy specimen. A brief review about sarcomatoid renal cell carcinoma is made.